Lamont Dozier began singing as a child in his grandmother's choir. By the age of ten he had written his first song. He first recorded with the Romeos at fifteen. In 1958 he met Berry Gordy Jr., and recorded as Lamont Anthony for Gordy's Anna Records label in 1961. Eddie Holland met Gordy in 1958 and dropped out of college to work for him. Holland had one of Motown's first hits "Jamie" in 1962. Brian Holland collaborated on two early hits for The Marvelettes, "Please Mr. Postman" and "Playboy."

In 1963, Brian and Eddie Holland and Lamont Dozier teamed up as a songwriting-production unit. Between 1963 and the end of 1967 H-D-H wrote majority of Motown's hit singles, with Brian writing the music, Eddie writing the lyrics, and Lamont doing both. Their hits included "Heat Wave," "Quicksand," and "Nowhere To Run" for Martha and The Vandellas, "Mickey's Monkey" for The Miracles, and "Can I Get a Witness," "Your a Wonderful One," and "How Sweet It Is (To Be Loved by You) for Marvin Gaye. Eddie Holland later collaborated with Norman Whitfield on "Ain't Too Proud to Beg," "Beauty Is Only Skin Deep," " (I Know) I'm Losing You" all hits for The Temptations.

Much of H-D-H best material was reserved for The Four Tops and The Supremes. Their hits for The Four Tops included "Baby I Need Your Loving," "I Can't Help Myself," "It's the Same Old Song," "Reach Out I'll Be There," "Standing In the Shadows of Love," and "Bernadette."

Their biggest success was with The Supremes whom they wrote ten Top 10 records. These included "Where Did Our Love Go," "Baby Love," "Come See About Me," "Stop! In the Name of Love," "I Hear a Symphony," "My World Is Empty Without You," "Love Is Like an Itching in My Heart," "You Can't Hurry Love," "You Keep Me Hangin' On," and "Love Is Here and Now You are Gone." H-D-H's "Reflections" and "In and Out of Love" were hits for Diana Ross and The Supremes.